Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a disabling and severe psychiatric disorder with a high rate of prevalence, and adolescence is one of the most probable periods for the first onset. The neurobiological mechanism underlying the adolescent MDD remains unexplored.

Methods

In this study, we examined the cortical and subcortical alterations of neuroanatomical structures and spontaneous functional activation in 50 unmedicated adolescents with MDD vs. 39 healthy controls through the combined structural and resting-state functional magnetic resonance imaging.

Results

Significantly altered regional gray matter volume was found at broader frontal-temporal-parietal and subcortical brain areas involved with various forms of information processing in adolescent MDD. S

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10113492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature