Apigenin is a promising molecule for treatment of visceral leishmaniasis.

ABSTRACT: Current treatment for visceral leishmaniasis is based on drugs such as pentavalent antimony and amphotericin B. However, this treatment remains mostly ineffective and expensive, resulting in several side effects and generating resistance. Apigenin, a flavonoid present in fruits and vegetables, has demonstrated several biological functions. In the present study, we observed a concentration-dependent inhibition of the L. infantum promastigote in the presence of apigenin, exhibiting an IC₅₀ value of 29.9 µM. Its effect was also evaluated in L. infantum-infected murine peritoneal macrophages, presenting an C₅₀ value against intracellular amastigotes of 2.3 µM and a selectivity index of 34.3. In a murine model of visceral leishmaniasis, the in vivo eff

SUBMITTER: Emiliano YSS 

PROVIDER: S-EPMC10113494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature