DegS protease regulates the motility, chemotaxis, and colonization of Vibrio cholerae.

ABSTRACT: In bacteria, DegS protease functions as an activating factor of the σ^E envelope stress response system, which ultimately activates the transcription of stress response genes in the cytoplasm. On the basis of high-throughput RNA sequencing, we have previously found that degS knockout inhibits the expression of flagellum synthesis- and chemotaxis-related genes, thereby indicating that DegS may be involved in the regulation of V. cholerae motility. In this study, we examined the relationships between DegS and motility in V. cholerae. Swimming motility and chemotaxis assays revealed that degS or rpoE deletion promotes a substantial reduction in the motility and chemotaxis of V. cholerae, whereas these activities were restored in ΔdegS::de

SUBMITTER: Zou M 

PROVIDER: S-EPMC10113495 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature