Monocyte signature as a predictor of chronic lung disease in the preterm infant.

ABSTRACT:

Introduction

Inflammation is a key driver of morbidity in the vulnerable preterm infant exposed to pre- and postnatal hazards and significantly contributes to chronic lung disease, i.e. bronchopulmonary dysplasia (BPD). However, the early changes in innate immunity associated with BPD development are incompletely understood.

Methods

In very immature preterm infants below 32 weeks gestational age (GA; n=30 infants), monocyte subtypes were identified by Flow Cytometry at birth and throughout the postnatal course including intracellular TNF expression upon LPS stimulation. Complementing these measurements, cytokine end growth factor expression profiles (Luminex^® xMAP^®; n=110 infants) as well as gene expression profiles (CodeLink^TM Human I

SUBMITTER: Windhorst AC 

PROVIDER: S-EPMC10113536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature