Murine macrophage-based iNos reporter reveals polarization and reprogramming in the context of breast cancer.

ABSTRACT: As part of the first line of defense against pathogens, macrophages possess the ability to differentiate into divergent phenotypes with varying functions. The process by which these cells change their characteristics, commonly referred to as macrophage polarization, allows them to change into broadly pro-inflammatory (M1) or anti-inflammatory (M2) subtypes, and depends on the polarizing stimuli. Deregulation of macrophage phenotypes can result in different pathologies or affect the nature of some diseases, such as cancer and atherosclerosis. Therefore, a better understanding of macrophage phenotype conversion in relevant models is needed to elucidate its potential roles in disease. However, there are few existing probes to track macrophage changes in multicellular environments. In this stu

SUBMITTER: Mas-Rosario JA 

PROVIDER: S-EPMC10113556 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature