Inhibitory effects of Stevioside on Streptococcus mutans and Candida albicans dual-species biofilm.

ABSTRACT:

Introduction

Streptococcus mutans is the most prevalent biofilm-forming pathogen in dental caries, while Candida albicans is often detected in the presence of S. mutans.

Methods

We aimed to evaluate the anti-caries effect of stevioside in medium trypticase soy broth (TSB) with or without sucrose supplementation compared with the same sweetness sucrose and xylitol in a dual-species model of S. mutans and C. albicans, based on planktonic growth, crystal violet assay, acid production, biofilm structural imaging, confocal laser scanning microscopy, and RNA sequencing.

Results

Our results showed that compared with sucrose, stevioside significantly inhibited planktonic growth and acid production, changed the structure of the mixed biofilm,

SUBMITTER: Guo M 

PROVIDER: S-EPMC10113668 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature