Impairment of substrate-mediated mitochondrial respiration in cardiac cells by chloroquine.

ABSTRACT: Chloroquine (CQ) has a long clinical history as an anti-malarial agent and also being used for the treatment of other infections and autoimmune diseases. Recently, this lysosomotropic agent and its derivatives are also been tested as adjuncts alongside conventional anti-cancer treatments in combinatorial therapies. However, their reported cardiotoxicity tends to raise concern over their indiscriminate use. Even though the influence of CQ and its derivatives on cardiac mitochondria is extensively studied in disease models, their impact on cardiac mitochondrial respiration under physiological conditions remains inconclusive. In this study, we aimed to evaluate the impact of CQ on cardiac mitochondrial respiration using both in-vitro and in-vivo model systems. Using high-resolution respiromet

SUBMITTER: Ashok S 

PROVIDER: S-EPMC10113731 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature