Berberine disrupts staphylococcal proton motive force to cause potent anti-staphylococcal effects in vitro.

ABSTRACT: The presence of antibiotic resistance has increased the urgency for more effective treatments of bacterial infections. Biofilm formation has complicated this issue as biofilm bacteria become tolerant to antibiotics due to environmental factors such as nutrient deprivation and adhesion. In septic arthritis, a disease with an 11% mortality rate, bacteria in synovial fluid organize into floating, protein-rich, bacterial aggregates (mm-cm) that display depressed metabolism and antibiotic tolerance. In this study, Staphylococcus aureus (S. aureus), which is the most common pathogen in septic arthritis, was tested against different inhibitors that modulate bacterial surface protein availability and that should decrease bacterial aggregation. One of these, berberine, a quaternary am

SUBMITTER: Zhao N 

PROVIDER: S-EPMC10113750 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature