Impact of particulate microplastics generated from polyethylene terephthalate on gut pathology and immune microenvironments.

ABSTRACT: Environmental microplastics have emerged as a critical issue in maintaining the planetary ecosystem. In this study, we generated particulate microplastics from polyethylene terephthalate (PM-PET) and investigated their impact in the gut by using mouse models and implementing histological examinations, as well as multi-omics analysis for colonic immune cells and microbiota. As a result, histological approaches showed that chronic and physiological low dose exposure of PM-PET did not affect intestinal pathology and mucin barriers, respectively. Moreover, immunohistochemical analysis demonstrated that the numbers of T cells, B cells, macrophages, and granulocytes were not affected by the exposure to PM-PET. However, RNA-seq analysis revealed that PM-PET had a substantial impact on the transcr

SUBMITTER: Harusato A 

PROVIDER: S-EPMC10113781 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature