Modelling hyperexcitability in human cerebral cortical organoids: Oxygen/glucose deprivation most effective stimulant.

ABSTRACT: Epilepsy is a common neurological disorder that affects 1% of the global population. The neonatal period constitutes the highest incidence of seizures. Despite the continual developments in seizure modelling and anti-epileptic drug development, the mechanisms involved in neonatal seizures remain poorly understood. This leaves infants with neonatal seizures at a high risk of death, poor prognosis of recovery and risk of developing neurological disorders later in life. Current in vitro platforms for modelling adult and neonatal epilepsies - namely acute cerebral brain slices or cell-derived cultures, both derived from animals-either lack a complex cytoarchitecture, high-throughput capabilities or physiological similarities to the neonatal human brain. Cerebral organoids, derived from

SUBMITTER: Saleem A 

PROVIDER: S-EPMC10113787 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature