Comparison of intergenerational instrumental variable analyses of body mass index and mortality in UK Biobank.

ABSTRACT:

Background

An increasing proportion of people have a body mass index (BMI) classified as overweight or obese and published studies disagree whether this will be beneficial or detrimental to health. We applied and evaluated two intergenerational instrumental variable methods to estimate the average causal effect of BMI on mortality in a cohort with many deaths: the parents of UK Biobank participants.

Methods

In Cox regression models, parental BMI was instrumented by offspring BMI using an 'offspring as instrument' (OAI) estimation and by offspring BMI-related genetic variants in a 'proxy-genotype Mendelian randomization' (PGMR) estimation.

Results

Complete-case analyses were performed in parents of 233 361 UK Biobank participants with full phenotypic, genotypic and cov

SUBMITTER: Barry CJ 

PROVIDER: S-EPMC10114047 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature