Sex differences in childhood cancer risk among children with major birth defects: a Nordic population-based nested case-control study.

ABSTRACT:

Background

Childhood cancer is more common among children with birth defects, suggesting a common aetiology. Whether this association differs by sex is unclear.

Methods

We performed a population-based nested case-control study using nationwide health registries in four Nordic countries. We included 21 898 cancer cases (0-19 years) and 218 980 matched population controls, born 1967-2014. Associations between childhood cancer and major birth defects were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) using logistic regression models. Effect modification was evaluated using a counterfactual framework to estimate confidence intervals and P-values for the natural indirect effects.

Results

Birth defects were present for 5.1% (1117/21 898) of childhood c

SUBMITTER: Daltveit DS 

PROVIDER: S-EPMC10114053 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature