Maternal type 1 diabetes, pre-term birth and risk of autism spectrum disorder-a prospective cohort study.

ABSTRACT:

Background

It has been suggested that maternal type 1 diabetes (T1D) increases the risk of autism spectrum disorder (ASD) in the offspring. However, it is unclear whether this risk is mediated by pre-term birth, affecting around one-third of pregnancies with T1D, and whether maternal levels of glycated haemoglobin (HbA1c) impact the risk.

Methods

A cohort of 1.4 million Swedish children born between 1998 and 2015, and their parents. Maternal T1D and HbA1c before or in early pregnancy, gestational and ASD diagnoses were obtained from Swedish national registers. Relative risk (RR) and 95% CIs of ASD were estimated by hazard ratios (HRs) from Cox regression or RR from log-binomial regression.

Results

Of 1 406 650 children, 8003 (0.6%) were born to mothers with T1D, 24 94

SUBMITTER: Persson M 

PROVIDER: S-EPMC10114059 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature