Childhood socio-economic circumstances and dementia: prospective register-based cohort study of adulthood socio-economic and cardiovascular health mediators.

ABSTRACT:

Background

This study analysed the association between childhood socio-economic circumstances and the risk of dementia, and investigated the mediating role of potentially modifiable risk factors including adulthood socio-economic position and cardiovascular health.

Methods

We used a 10% sample of the 1950 Finnish population census linked with subsequent population and health registers (n = 95 381). Information of socio-economic characteristics, family structure and housing conditions at the age of 0-15 years was obtained from the 1950 census. We identified cohort members who developed dementia in 2000-2018 using national hospital, medication and death registers. Discrete time survival analysis using logistic regression and mediation analysis applying the Karlson-Holm-Breen (

SUBMITTER: Korhonen K 

PROVIDER: S-EPMC10114069 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature