Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.

ABSTRACT: Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which increases the risk of various cancers that display characteristic patterns of accumulated mutations arising from the causative exposures. Tracking the contributions of individual mutagens to mutational signatures present in human cancers can help understand cancer etiology and advance disease prevention strategies. To characterize the potential contributions of individual constituents of tobacco smoke to tobacco exposure-associated mutational signatures, we first assessed the toxic potential of 13 tobacco-relevant compounds by determining their impact on the viability of a human bronchial lung epithelial cell line (BEAS-2B). Experimentall

SUBMITTER: Mingard C 

PROVIDER: S-EPMC10114081 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature