Asthma inflammatory phenotypes on four continents: most asthma is non-eosinophilic.

ABSTRACT:

Background

Most studies assessing pathophysiological heterogeneity in asthma have been conducted in high-income countries (HICs), with little known about the prevalence and characteristics of different asthma inflammatory phenotypes in low-and middle-income countries (LMICs). This study assessed sputum inflammatory phenotypes in five centres, in Brazil, Ecuador, Uganda, New Zealand (NZ) and the United Kingdom (UK).

Methods

We conducted a cross-sectional study of 998 asthmatics and 356 non-asthmatics in 2016-20. All centres studied children and adolescents (age range 8-20 years), except the UK centre which involved 26-27 year-olds. Information was collected using questionnaires, clinical characterization, blood and induced sputum.

Results

Of 623 asthmatics with sputum

SUBMITTER: Pembrey L 

PROVIDER: S-EPMC10114118 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature