Mortality among twin individuals exposed to loss of a co-twin.

ABSTRACT:

Background

Although the death of a child, sibling or spouse has been associated with elevated risk of mortality, less is known about the survival of twin siblings exposed to a co-twin loss.

Methods

In a Swedish population-based sibling-matched cohort, we compared the mortality of 5548 twin individuals who lost their co-twin between 1932 and 2011 with that of 27 740 age-matched and sex-matched twin individuals without such a loss and 6772 full siblings of these exposed twin individuals. Cox regression models were used to estimate the hazard ratios (HRs) of all-cause and cause-specific mortality.

Results

We found increased risk of all-cause mortality among twin individuals exposed to a co-twin loss compared with matched unexposed twin individuals (HR = 1.30, 95% CI: 1.1

SUBMITTER: Song H 

PROVIDER: S-EPMC10114119 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature