Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis.

ABSTRACT:

Introduction

Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14).

Methods

Expression levels of MAPK14 and its associated lncRNAs were measured in the circulation of MS patients compared with control subjects.

Results

Expression levels of NORAD and RAD51-AS1 were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04-1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43-2.6), P value = 0.0001, respectively). Conversely, ZNRD1ASP was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41-0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset.

Conclusion

To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients.

SUBMITTER: Ghafouri-Fard S 

PROVIDER: S-EPMC10114144 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature