Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.

ABSTRACT:

Background

Age-related changes in immune cell composition and functionality are associated with multimorbidity and mortality. However, many centenarians delay the onset of aging-related disease suggesting the presence of elite immunity that remains highly functional at extreme old age.

Methods

To identify immune-specific patterns of aging and extreme human longevity, we analyzed novel single cell profiles from the peripheral blood mononuclear cells (PBMCs) of a random sample of 7 centenarians (mean age 106) and publicly available single cell RNA-sequencing (scRNA-seq) datasets that included an additional 7 centenarians as well as 52 people at younger ages (20-89 years).

Findings

The analysis confirmed known shifts in the ratio of lymphocytes to myeloid cells, and nonc

SUBMITTER: Karagiannis TT 

PROVIDER: S-EPMC10114155 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature