Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction.

ABSTRACT:

Introduction

Plasma concentrations of gut microbial metabolites are associated with cardiomyocyte viability and platelet reactivity. We hypothesized that increased concentrations of gut metabolites may predict major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI).

Aim

The primary objective of this study was to evaluate the association between elevated plasma concentrations of gut metabolites and MACCE after AMI.

Material and methods

We compared plasma concentrations of gut metabolites (trimethylamine-N-oxide (TMAO) and indoxyl sulphate (IS)) and platelet reactivity in 57 patients with AMI and 27 healthy controls. We assessed the predictive value of gut metabolites for MACCE (stroke, recurrent AMI, death) over a median of 3.5-

SUBMITTER: Gasecka A 

PROVIDER: S-EPMC10114180 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature