The role of puberty on physical and brain development: A longitudinal study in male Rhesus Macaques.

ABSTRACT: This study examined the role of male pubertal maturation on physical growth and development of neurocircuits that regulate stress, emotional and cognitive control using a translational nonhuman primate model. We collected longitudinal data from male macaques between pre- and peri-puberty, including measures of physical growth, pubertal maturation (testicular volume, blood testosterone -T- concentrations) and brain structural and resting-state functional MRI scans to examine developmental changes in amygdala (AMY), hippocampus (HIPPO), prefrontal cortex (PFC), as well as functional connectivity (FC) between those regions. Physical growth and pubertal measures increased from pre- to peri-puberty. The indexes of pubertal maturation -testicular size and T- were correlated at peri-puberty, but

SUBMITTER: Kovacs-Balint ZA 

PROVIDER: S-EPMC10114189 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature