N ⁶-methyladenosine modification contributes to respiratory syncytial virus infection.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is the second leading cause of death due to lower respiratory tract infections. Effective prevention and treatment measures are lacking, posing a huge socioeconomic burden to the world. N ⁶-methyladenosine (m⁶A) is the most common internal modification in messenger RNA and noncoding RNA. Numerous recent studies have shown that the dysregulation of m⁶A modification is associated with diseases caused by pathogenic viruses.

Methods

The changes in m⁶A modification were evaluated using m⁶A RNA methylation assay. The differences in gene expression levels of various m⁶A-modifying enzymes were observed using Quantitative Real-time PCR (qRT-PCR) during RSV infection.

SUBMITTER: Li Z 

PROVIDER: S-EPMC10114233 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature