Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders.

ABSTRACT:

Introduction

Psychiatric disorders are common and significantly impact the quality of life. Inflammatory processes are proposed to contribute to the emergence of psychiatric disorders. In addition to inflammation, disturbances in metabolic pathways have been observed in individuals with different psychiatric disorders. A suggested key player in the interaction between inflammation and metabolism is the Nod-like receptor 3 (NLRP3) inflammasome, and NLRP3 is known to react to a number of specific metabolites. However, little is known about the interplay between these immunometabolites and the NLRP3 inflammasome in mental health disorders.

Aim

To assess the interplay between immunometabolites and inflammasome function in a transdiagnostic cohort of individuals with severe menta

SUBMITTER: Hylen U 

PROVIDER: S-EPMC10114326 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature