Assessing the impact of the early COVID-19 era on antibiotic resistant threats in inpatient settings: A mixed-Poisson regression approach.

ABSTRACT:

Background

During the COVID-19 pandemic, increased antibiotic prescribing and infection prevention challenges coincided with antibiotic resistant (AR) infection increases. Clostridioides difficile (C. difficile) and methicillin-resistant Staphylococcus aureus (MRSA) are serious, costly AR threats. Health inequities in pandemic-era AR infections are not well-characterized.

Methods

North Carolina statewide inpatient admissions were used to determine monthly admission rates and admission rate ratios (RRs) for C. difficile and MRSA infections comparing 2017-2019 (pre-pandemic) to 2020 (pandemic exposure) using mixed-model Poisson regression adjusted for age, sex, comorbidities, and COVID-19. We assessed effect measure modification (EMM) by admissions' community-level income, cou

SUBMITTER: Bloch R 

PROVIDER: S-EPMC10114351 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature