The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Positive associations between the risk of schizophrenia and the level of white blood cells (WBC) count have been suggested by observational studies. However, the causality of this association is still unclear.

Methods

We used a group of bidirectional two-sample Mendelian randomization (MR) analyses to estimate the causal relationship between schizophrenia and WBC count traits (i.e., WBC count, lymphocyte count, neutrophil count, basophil count, eosinophil count, and monocyte count). The threshold of FDR-adjusted P < 0.05 was considered as showing potential evidence of a causal effect. Instrument variables were included based on the genome-wide significance threshold (P < 5 × 10^- 8) and linkage disequilibrium (LD) clumping (r² < 0.01). In tota

SUBMITTER: Gao Z 

PROVIDER: S-EPMC10114369 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature