PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model.

ABSTRACT:

Background

Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache responses in preclinical models. It is also well known that vasodilators such as nitric oxide (NO) donors can trigger migraine attacks in migraine patients but not controls. In the current study we examined whether activation of PAR2 in the dura causes priming to the NO donor glyceryl trinitrate (GTN).

Methods

A preclinical behavioral model of migraine was used where stimuli (PAR2 agonists: 2at-LIGRL-NH₂ (2AT) or neutrophil elastase (NE); and IL-6) were applied to the mouse dura through an injection made at the intersection of the lamdoidal and sagittal su

SUBMITTER: Mason BN 

PROVIDER: S-EPMC10114383 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature