Clinical prediction models for serious infections in children: external validation in ambulatory care.

ABSTRACT:

Background

Early distinction between mild and serious infections (SI) is challenging in children in ambulatory care. Clinical prediction models (CPMs), developed to aid physicians in clinical decision-making, require broad external validation before clinical use. We aimed to externally validate four CPMs, developed in emergency departments, in ambulatory care.

Methods

We applied the CPMs in a prospective cohort of acutely ill children presenting to general practices, outpatient paediatric practices or emergency departments in Flanders, Belgium. For two multinomial regression models, Feverkidstool and Craig model, discriminative ability and calibration were assessed, and a model update was performed by re-estimation of coefficients with correction for overfitting. For two ris

SUBMITTER: Bos DAG 

PROVIDER: S-EPMC10114467 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature