Maternal stress as a risk factor for non-syndromic orofacial clefts: Systematic review and meta-analysis.

ABSTRACT:

Background

Non-syndromic orofacial clefts (NSOFC) are among the most common congenital malformations. Several studies have investigated the association between stress and NSOFC; however, they have reported different and heterogeneous results. Therefore, this systematic review was conducted to investigate the association between maternal periconceptional stress and non-syndromic orofacial clefts in infants.The research question was "Is maternal periconceptional stress an etiological factor for non-syndromic orofacial clefts in infants"?

Methods

Search strategy, inclusion/exclusion criteria, and data extraction from studies reporting periconceptional maternal exposure to stress and NSOFC were implemented without language restrictions. The risks of bias in the identified

SUBMITTER: Talal AlSharif M 

PROVIDER: S-EPMC10114596 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature