Phylogenetic landscape of Monkeypox Virus (MPV) during the early outbreak in New York City, 2022.

ABSTRACT: Monkeypox (MPOX) is a zoonotic disease endemic to regions of Central/Western Africa. The geographic endemicity of MPV has expanded, broadening the human-monkeypox virus interface and its potential for spillover. Since May 2022, a large multi-country MPV outbreak with no proven links to endemic countries has originated in Europe and has rapidly expanded around the globe, setting off genomic surveillance efforts. Here, we conducted a genomic analysis of 23 MPV-infected patients from New York City during the early outbreak, assessing the phylogenetic relationship of these strains against publicly available MPV genomes. Additionally, we compared the genomic sequences of clinical isolates versus culture-passaged samples from a subset of samples. Phylogenetic analysis revealed that MPV genomes i

SUBMITTER: Patino LH 

PROVIDER: S-EPMC10114986 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature