The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men.

ABSTRACT:

Background & aims

This study aimed to analyse the association of sex hormone levels with liver enzyme levels and non-alcoholic fatty liver disease (NAFLD) in a nationally representative sample of men.

Methods

A total of 919 men from the US National Health and Nutrition Examination Study (NHANES) III were included in this cross-sectional analysis of data from 1988 to 1991. We used existing data on serum total and free testosterone, total and free estradiol, androstanediol glucuronide (AAG) and sex steroid-binding globulin (SHBG), and estimated their associations with aspartate aminotransferase (AST), and alanine aminotransferase (ALT) and NAFLD, as determined using ultrasound, after adjusting for possible confounders including age, race, smoking, alcohol, physical activity, w

SUBMITTER: Phan H 

PROVIDER: S-EPMC10115140 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature