Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke.

ABSTRACT:

Objective

Clinical associations between coronavirus disease (COVID-19) and ischemic stroke (IS) have been reported. This study aimed to investigate the shared genes between COVID-19 and IS and explore their regulatory mechanisms.

Methods

Published datasets for COVID-19 and IS were downloaded. Common differentially expressed genes (DEGs) in the two diseases were identified, followed by protein-protein interaction (PPI) network analysis. Moreover, overlapping module genes associated with the two diseases were investigated using weighted correlation network analysis (WGCNA). Through intersection analysis of PPI cluster genes and overlapping module genes, hub-shared genes associated with the two diseases were obtained, followed by functional enrichment analysis and external data

SUBMITTER: Wu H 

PROVIDER: S-EPMC10115163 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature