Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease.

ABSTRACT: Markers of downstream events are a key component of clinical trials of disease-modifying therapies for Alzheimer's disease. Morphological metrics like cortical thickness are established measures of atrophy but are not sensitive enough to detect amyloid-beta (Aβ)- related changes that occur before overt atrophy become visible. We aimed to investigate to what extent diffusion MRI can provide sensitive markers of cortical microstructural changes and to test their associations with multiple aspects of the Alzheimer's disease pathological cascade, including both Aβ and tau accumulation, astrocytic activation and cognitive deficits. We applied the mean apparent diffusion propagator model to diffusion MRI data from 492 cognitively unimpaired elderly and patients with mild cognitive impairment fro

SUBMITTER: Spotorno N 

PROVIDER: S-EPMC10115177 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature