Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors.

ABSTRACT: Neutrophils are critical for the direct eradication of Aspergillus fumigatus conidia, but whether they mediate antifungal defense beyond their role as effectors is unclear. In this study, we demonstrate that neutrophil depletion impairs the activation of protective antifungal CCR2⁺ inflammatory monocytes. In the absence of neutrophils, monocytes displayed limited differentiation into monocyte-derived dendritic cells, reduced formation of reactive oxygen species, and diminished conidiacidal activity. Upstream regulator analysis of the transcriptional response in monocytes predicted a loss of STAT1-dependent signals as the potential basis for the dysfunction seen in neutrophil-depleted mice. We find that conditional removal of STAT1 on CCR2⁺ cells results in dimi

SUBMITTER: Espinosa V 

PROVIDER: S-EPMC10115354 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature