Chronic ocular sequelae in Stevens-Johnson syndrome: a genetic association study.

ABSTRACT:

Purpose

This study sought to investigate the association of molecular markers with chronic ocular sequelae in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Methods

One hundred SJS/TEN patients (200 eyes) with confirmed diagnosis were enrolled between July 2011 and July 2015 from a tertiary eye-care hospital, and their clinical histories were noted. Each eye was scored for severity of manifestation on a scale of 0-5. Peripheral blood samples were collected for DNA followed by screening for interleukin (IL-4, IL-13, IL-4R) polymorphisms, HLA-A locus allele typing, and sera to detect levels of the apoptotic markers granulysin and sFas L.

Results

Of the 100 enrolled patients (53 males/47 females; age range: 6-58 years), the incriminating drugs were non-st

SUBMITTER: Sangwan SK 

PROVIDER: S-EPMC10115362 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature