Analysis of hemopexin plasma levels in patients with age-related macular degeneration.

ABSTRACT:

Purpose

A protein quantitative trait locus (pQTL) analysis recently revealed a strong association between hemopexin (HPX) levels and genetic variants at the complement factor H (CFH) locus. In this study, we aimed to determine HPX plasma levels in patients with age-related macular degeneration (AMD) and to compare them with those in controls. We also investigated whether genetic variants at the CFH locus are associated with HPX plasma levels.

Methods

HPX levels were quantified in 200 advanced AMD cases and 200 controls using an enzyme-linked immunosorbent assay and compared between the two groups. Furthermore, HPX levels were analyzed per genotype group of three HPX-associated variants (rs61818956, rs10494745, and rs10801582) and four AMD-associated variants (r

SUBMITTER: Lauwen S 

PROVIDER: S-EPMC10115365 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature