Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis.

ABSTRACT:

Introduction

International guidelines provide heterogenous guidance on use of corticosteroids for community-acquired pneumonia (CAP).

Methods

We performed a systematic review of randomized controlled trials examining corticosteroids in hospitalized adult patients with suspected or probable CAP. We performed a pairwise and dose-response meta-analysis using the restricted maximum likelihood (REML) heterogeneity estimator. We assessed the certainty of the evidence using GRADE methodology and the credibility of subgroups using the ICEMAN tool.

Results

We identified 18 eligible studies that included 4661 patients. Corticosteroids probably reduce mortality in more severe CAP (RR 0.62 [95% CI 0.45 to 0.85]; moderate certainty) with possibly no effect in less severe CAP (RR 1

SUBMITTER: Pitre T 

PROVIDER: S-EPMC10115386 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature