Structural and functional properties of a plant NRAMP-related aluminum transporter.

ABSTRACT: The transport of transition metal ions by members of the SLC11/NRAMP family constitutes a ubiquitous mechanism for the uptake of Fe²⁺ and Mn²⁺ across all kingdoms of life. Despite the strong conservation of the family, two of its branches have evolved a distinct substrate preference with one mediating Mg²⁺ uptake in prokaryotes and another the transport of Al³⁺ into plant cells. Our previous work on the SLC11 transporter from Eggerthella lenta revealed the basis for its Mg²⁺ selectivity (Ramanadane et al., 2022). Here, we have addressed the structural and functional properties of a putative Al³⁺ transporter from Setaria italica. We show that the protein transports diverse divalent metal ions and binds the triva

SUBMITTER: Ramanadane K 

PROVIDER: S-EPMC10115441 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature