Identification of protein-protein interaction bridges for multiple sclerosis.

ABSTRACT:

Motivation

Identifying and prioritizing disease-related proteins is an important scientific problem to develop proper treatments. Network science has become an important discipline to prioritize such proteins. Multiple sclerosis, an autoimmune disease for which there is still no cure, is characterized by a damaging process called demyelination. Demyelination is the destruction of myelin, a structure facilitating fast transmission of neuron impulses, and oligodendrocytes, the cells producing myelin, by immune cells. Identifying the proteins that have special features on the network formed by the proteins of oligodendrocyte and immune cells can reveal useful information about the disease.

Results

We investigated the most significant protein pairs that we define as bridges amon

SUBMITTER: Yazıcı G 

PROVIDER: S-EPMC10115466 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature