Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study.

ABSTRACT: We assessed the efficacy and safety of PB compared with benzodiazepine (BZD)-based protocols in treating AWS in MICU.

Design

Single-center, pre-post protocol implementation study.

Setting

The setting is a forty-bed MICU in a tertiary-level academic medical center.

Patients

We included all patients admitted to the MICU with a primary diagnosis of AWS.

Interventions

Intravenous PB 260 mg followed by 130-mg doses every 15-30 minutes as needed up to 15 mg/kg of ideal body weight versus escalating doses of BZD, to achieve a Clinical Institute Withdrawal Assessment Alcohol Scale-Revised score less than 10.

Measurements and main results

ICU and hospital length of stay (LOS), in addition to safety measures were the main outcomes of the study. A total of 102 patie

SUBMITTER: Alwakeel M 

PROVIDER: S-EPMC10115550 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature