Dysbiosis of a microbiota-immune metasystem in critical illness is associated with nosocomial infections.

ABSTRACT: Critically ill patients in intensive care units experience profound alterations of their gut microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections and adverse outcomes through unclear mechanisms. Abundant mouse and limited human data suggest that the gut microbiota can contribute to maintenance of systemic immune homeostasis, and that intestinal dysbiosis may lead to defects in immune defense against infections. Here we use integrated systems-level analyses of fecal microbiota dynamics in rectal swabs and single-cell profiling of systemic immune and inflammatory responses in a prospective longitudinal cohort study of critically ill patients to show that the gut microbiota and systemic immunity function as an integrated metasystem, where intestinal dys

SUBMITTER: Schlechte J 

PROVIDER: S-EPMC10115642 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature