The evolution of lung cancer and impact of subclonal selection in TRACERx.

ABSTRACT: Lung cancer is the leading cause of cancer-associated mortality worldwide¹. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adeno

SUBMITTER: Frankell AM 

PROVIDER: S-EPMC10115649 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature