Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections.

ABSTRACT: Introduction: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp., commonly referred to as TriTryps, are a group of protozoan parasites that cause important human diseases affecting millions of people belonging to the most vulnerable populations worldwide. Current treatments have limited efficiencies and can cause serious side effects, so there is an urgent need to develop new control strategies. Presently, the identification and prioritization of appropriate targets can be aided by integrative genomic and computational approaches. Methods: In this work, we conducted a genome-wide multidimensional data integration strategy to prioritize drug targets. We included genomic, transcriptomic, metabolic, and protein structural data sources, to delineate c

SUBMITTER: Rivara-Espasandin M 

PROVIDER: S-EPMC10115950 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature