Inflammation-related proteomics demonstrate landscape of fracture blister fluid in patients with acute compartment syndrome.

ABSTRACT:

Background

Blisters are tense vesicles or bullae that arise on swollen skin and are found in a wide range of injuries. As a complication of fracture, fracture blisters are considered soft tissue injuries, which often lead to adverse effects such as prolonged preoperative waiting time and increased risk of surgical site infection. However, our previous study found that in patients with acute compartment syndrome, fracture blisters may be a form of compartment pressure release, but the specific mechanism has not been revealed. Here, we mapped out the proteomic landscape of fracture blister fluid for the first time and compared its expression profile to cupping and burn blisters.

Methods

First, fluid samples were collected from 15 patients with fracture blisters, 7 patients wit

SUBMITTER: Long Y 

PROVIDER: S-EPMC10115951 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature