Integrating transcriptomics and metabolomics to analyze the mechanism of hypertension-induced hippocampal injury.

ABSTRACT:

Objective

Hypertension is a public health challenge worldwide due to its high prevalence and multiple complications. Hypertension-induced damage to the hippocampus leads to behavioral changes and various brain diseases. Despite the multifaceted effects of hypertension on the hippocampus, the mechanisms underlying hippocampal lesions are still unclear.

Methods

The 32-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were selected as the study subjects. Behavioral experiments such as an open field test (OFT), an elevated plus maze (EPM) test, and the Morris water maze (MWM) test were performed to show the behavioral characteristics of the rats. A comprehensive transcriptomic and metabolomic analysis was performed to understand the changes in the hippoc

SUBMITTER: Li Y 

PROVIDER: S-EPMC10115962 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature