M ycobacterium avium complex genomics and transmission in a London hospital.

ABSTRACT:

Background

Non-tuberculous mycobacteria (NTM) are environmental microorganisms and opportunistic pathogens in individuals with pre-existing lung conditions such as cystic fibrosis (CF) and non-CF bronchiectasis. While recent studies of Mycobacterium abscessus have identified transmission within single CF centres as well as nationally and globally, transmission of other NTM species is less well studied.

Methods

To investigate the potential for transmission of the Mycobacterium avium complex (MAC) we sequenced 996 isolates from 354 CF and non-CF patients at the Royal Brompton Hospital (London, UK; collected 2013-2016) and analysed them in a global context. Epidemiological links were identified from patient records. Previously published genomes were used to charac

SUBMITTER: van Tonder AJ 

PROVIDER: S-EPMC10116071 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature