Dataset Information

Monitoring of the microcirculation in children undergoing major abdominal and thoracic surgery: A pilot study.

ABSTRACT:

Background

Monitoring of the macrocirculation during surgery provides limited information on the quality of organ perfusion.

Objective

We investigated the feasibility of perioperative microcirculatory measurements in children.

Methods

Sublingual microvessels were visualized by handheld videomicroscopy in 11 children (19 mo - 10 yrs) undergoing surgery > 120 min at four time points: T0) after induction of anesthesia; T1) before end of anesthesia, T2) 6 h post surgery and T3) 24 h post surgery.

Results

Measurements were feasible in all children at T0 and T1. At T2 and T3, imaging was restricted to 6 and 4 infants, respectively, due to respiratory compromise and missing cooperation. The capillary density was reduced at T1 compared to T0 (8.1 mm/mm2 [4.0-17.0] vs. 10.6 mm/mm2 [5.1-19.3]; p = 0.01), and inversely related to norepinephrine dose (Pearson r = -0.65; p = 0.04). Microvascular flow and serum glycocalyx makers Syndecan-1 and Hyaluronan increased significantly from T0 to T1.

Conclusion

Perioperative microcirculatory monitoring in children requires a high amount of personal and logistic resources still limiting its routine use. Major surgery is associated with microvascular alterations and glycocalyx perturbation. The possible consequences on patient outcome need further evaluation. Efforts should concentrate on the development of next generation devices designed to facilitate microcirculatory monitoring in children.

SUBMITTER: Wagner M

PROVIDER: S-EPMC10116146 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Monitoring of the microcirculation in children undergoing major abdominal and thoracic surgery: A pilot study.

Wagner Marie M Anzinger Eveline E Hey Florian F Reiter Karl K Wermelt Julius Z JZ Pastor-Villaescusa Belén B Genzel-Boroviczény Orsolya O Nussbaum Claudia C

Clinical hemorheology and microcirculation 20230101 3

<h4>Background</h4>Monitoring of the macrocirculation during surgery provides limited information on the quality of organ perfusion.<h4>Objective</h4>We investigated the feasibility of perioperative microcirculatory measurements in children.<h4>Methods</h4>Sublingual microvessels were visualized by handheld videomicroscopy in 11 children (19 mo - 10 yrs) undergoing surgery > 120 min at four time points: T0) after induction of anesthesia; T1) before end of anesthesia, T2) 6 h post surgery and T3) ...[more]

PMID: 36502307

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Dataset Information

Monitoring of the microcirculation in children undergoing major abdominal and thoracic surgery: A pilot study.

Background

Objective

Methods

Results

Conclusion

Publications

Monitoring of the microcirculation in children undergoing major abdominal and thoracic surgery: A pilot study.

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