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Understanding the genetics of intracranial aneurysms: A primer.

ABSTRACT: The genetics of intracranial aneurysms is complex. Much work has been done looking at the extracellular matrix surrounding cerebral vasculature as well as the role of matrix metalloproteinases. This comprehensive review summarizes what is known to date about the important genetic components that predispose to aneurysm formation and critically discusses the published findings. We discuss promising pre-clinical models of aneurysm formation and subarachnoid hemorrhage, and highlight avenues for future discovery, while considering limitations in the research to date. This review will further serve as a comprehensive reference guide to understand the genetic underpinnings for aneurysm pathophysiology and act as a primer for further investigation.

SUBMITTER: Laurent D

PROVIDER: S-EPMC10116189 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Understanding the genetics of intracranial aneurysms: A primer.

Laurent Dimitri D Small Coulter C Lucke-Wold Brandon B Dodd William S WS Chalouhi Nohra N Hu Yin C YC Hosaka Koji K Motwani Kartik K Martinez Melanie M Polifka Adam A Koch Matthew M Busl Katharina M KM Maciel Carolina B CB Hoh Brian B

Clinical neurology and neurosurgery 20211125

The genetics of intracranial aneurysms is complex. Much work has been done looking at the extracellular matrix surrounding cerebral vasculature as well as the role of matrix metalloproteinases. This comprehensive review summarizes what is known to date about the important genetic components that predispose to aneurysm formation and critically discusses the published findings. We discuss promising pre-clinical models of aneurysm formation and subarachnoid hemorrhage, and highlight avenues for fut ...[more]

PMID: 34863053

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