Postprandial dysfunction in fatty liver disease.

ABSTRACT: Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important. Here, we investigated postprandial changes in markers of metabolic dysfunction between healthy individuals, obese individuals with non-alcoholic fatty liver disease (NAFLD) and patients with cirrhosis. We included individuals with biopsy-proven NAFLD (n = 9, mean age 50 years, mean BMI 35 kg/m² , no/mild fibrosis), cirrhosis with hepatic steatosis (n = 10, age 62 years, BMI 32 kg/m² , CHILD A/B) and healthy controls (n = 10, age 23, BMI 25 kg/m² ), randomized 1:1 to fasting or standardized mixed meal test (postprandial). None of the patients randomized to mixed me

SUBMITTER: Grandt J 

PROVIDER: S-EPMC10116394 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature