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Absorption, metabolism, and excretion of [¹⁴ C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers.

ABSTRACT: Dersimelagon (formerly MT-7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being investigated for the treatment of erythropoietic protoporphyria, X-linked protoporphyria, and diffuse cutaneous systemic sclerosis (dcSSc). Findings of studies evaluating the absorption, distribution, metabolism, and excretion (ADME) of dersimelagon following a single dose of [¹⁴ C]dersimelagon in healthy adult volunteers (N = 6) who participated in phase 1, single-center, open-label, mass balance study (NCT03503266), and in preclinical animal models are presented. Rapid absorption and elimination were observed following oral administration of [¹⁴ C]dersimelagon in clinical and nonclinical studies, with a mean T_ma

SUBMITTER: Tsuda M

PROVIDER: S-EPMC10116397 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Dataset Information

Absorption, metabolism, and excretion of [¹⁴ C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers.

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Dataset Information

Absorption, metabolism, and excretion of [14 C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Absorption, metabolism, and excretion of [¹⁴ C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers.