Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes.

ABSTRACT:

Introduction

Exposure to space conditions during crewed long-term exploration missions can cause several health risks for astronauts. Space radiation, isolation and microgravity are major limiting factors. The role of astrocytes in cognitive disturbances by space radiation is unknown. Astrocytes' response toward low linear energy transfer (LET) X-rays and high-LET carbon (¹²C) and iron (⁵⁶Fe) ions was compared to reveal possible effects of space-relevant high-LET radiation. Since astronauts are exposed to ionizing radiation and microgravity during space missions, the effect of simulated microgravity on DNA damage induction and repair was investigated.

Methods

Primary murine cortical astrocytes were irradiated with different doses of X-rays, ¹²

SUBMITTER: Roggan MD 

PROVIDER: S-EPMC10116417 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature